There were about twice as many recurrences among the people taking placebos. Osimertinib also appeared to reduce disease recurrence. Each patient took the medicine for three years unless they had to discontinue it, and they were monitored for a median of five years (although some were followed for up to 6.8 years total).Īfter five years, 88 percent of patients on osimertinib remained alive, compared with 78 percent of the control population-meaning that the drug about halved the risk of death during the five-year period. (This scale goes up to stage 4, which is the most severe.) Some participants had also completed chemotherapy treatments. All the participants had had a tumor surgically removed, and their cancers were considered stage 1, 2 or 3. Just under half of them took osimertinib once a day the others took a placebo pill. The trial included 682 patients with the mutation, called T790M. “We expected this would work but not this well,” he says. But for them, Herbst says, early treatment with the drug could make a big difference. The new findings will only be relevant for a small fraction of people who have a specific type of genetic mutation. Osimertinib is what scientists call a tyrosine kinase inhibitor, a substance that affects a class of enzymes involved in cell signaling, growth and division. cancer deaths in 2020, according to the Centers for Disease Control and Prevention. It’s also the deadliest, responsible for nearly a quarter of U.S. The American Cancer Society expects more than 230,000 new cases to be reported this year. Lung cancer is one of the most common cancers in the U.S. “It’s really taking personalized therapy from advanced metastatic disease and moving it all the way to the earliest stages of lung cancer treatment,” Herbst says. The new study offers evidence that the same drug can improve outcomes for people with earlier stages of lung cancer, says Roy Herbst, deputy director of the Yale Cancer Center and co-lead author of the paper. The trial findings were published on June 4 in the New England Journal of Medicine and presented on the same day at the annual meeting of the American Society of Clinical Oncology in Chicago. Food and Drug Administration granted it an accelerated approval in 2015. ![]() ![]() ![]() It has been used to treat later-stage lung cancer since the U.S. The drug is called osimertinib, which AstraZeneca Pharmaceuticals produces under the brand name Tagrisso. A daily pill may halve the risk of death for lung cancer patients with a particular type of genetic mutation who have undergone surgery, according to much awaited clinical trial results.
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